Utilization of Various Phosphoryl Halides and Imidazolides for the Conversion of Aldoximes to Nitriles
نویسندگان
چکیده
Although, over the years, considerable interest has been shown in the transformation of aldoximes to nitriles, surprisingly few attempts have been made in utilizing derivatives of phosphorus for this purpose [1-7]. Best results were achieved using aromatic aldoximes, and only seldom were aliphatic aldoximes utilized, affording nitriles in only moderate yields. Recently [8], we reported a novel approach for the preparation of aliphatic and aromatic nitriles via aldoximes utilizing the spin-labeled imidazolides of phosphorus 1 [9] and 2 [10]. In most
منابع مشابه
The Utilization of Sulfur, Sulfenyl, Selenenyl, and Seleninyl Chlorides in the Conversion of Aldoximes to Nitriles
G e o r g e S o s n o v s k y a n d J a m e s A . K r o g h Department of Chemistry, University o f Wisconsin-Milwaukee, Milwaukee, Wisconsin 53201, U S A Z. Naturforsch. 84b , 511-515 (1979); received N o v e m b e r 28, 1978 Sulfur Chlorides and Disulfides, Conversion o f Aldehydes to Nitriles, Selenium Chlorides and Diselenides, Nitriles, A ldox imes The comparat ive usefulness of six sulfur...
متن کاملConversion of aldoximes into nitriles and amides under mild conditions.
A series of Pd(en)X2 salts were used as catalysts for the conversion of aldoximes into nitriles and amides. Highlights of this protocol include the use of inexpensive polar solvents, including water, and moderate reaction temperatures. A high degree of selectivity in the reaction outcome was observed when using aliphatic vs. aromatic/conjugated aldoximes.
متن کاملFe(HSO4)3-Catalyzed Direct Conversion of Aldehydes into Nitriles Using Hydroxylamine Hydrochloride
Due to the importance and various applications of nitriles especially in medicinal productions, a new method for conversion of aldehydes to nitriles has been presented. Several nitrile-containing aromatic compounds were synthesized through the treatment of various aldehydes and hydroxylamine hydrochloride as nucleophile in the presence of ferric hydrogen sulfate as a heterogeneous, efficient, a...
متن کاملThe direct synthesis of N-alkylated amides via a tandem hydration/N-alkylation reaction from nitriles, aldoximes and alcohols.
A novel strategy for the direct synthesis of N-alkylated amides from nitriles, aldoximes and alcohols was proposed and accomplished in the presence of a Cp*Ir complex.
متن کامل